AAI (autologous anti-inflammatory injection or ‘nSTRIDE’) offers the ability to readdress the imbalance between anti-inflammatory and pro-inflammatory cytokines in the osteoarthritic knee by boosting the concentration of the patients’ own anti-inflammatory cytokines.
Increased concentrations of anti-inflammatory (‘good’) cytokines result in the blockade of pro-inflammatory (‘bad’) cytokines and therefore reduce the activation of pro-inflammatory enzymes. This reduces the damage to the articular cartilage and therefore slows down progression of osteoarthritis.
As a result of reducing the inflammatory environment in the knee, pain pathways are inactivated and therefore patients experience a significant improvement in both pain and function.
AAI (‘nSTRIDE') also contains a high concentration of the patients’ own regenerative proteins and there is some evidence to suggest that some of the degenerative changes of osteoarthritis may be reversed to an extent.
AAI (‘nSTRIDE') has been in clinical use for over 4 years. There is now a body of evidence supporting it’s use and demonstrating good clinical results. Studies demonstrate that 82% of people with mild to moderate osteoarthritis still experience significant improvement in pain and function at 1 year after the procedure; 73% still experience that improvement at 2 years post-procedure and 70% at 3 years post-procedure.
It often takes around 4 weeks for patients to start to see improvement in pain and function within the knee. This is because it takes time for the inflammatory environment to be modified by the AAI ('nSTRIDE') injection and activation of the pain pathways to be reduced. Once the effects of the AAI procedure start to be felt the improvement typically continues to improve gradually for a further 6 – 9 months then reaches a plateau level. As reported above, 82% of patients will still have this improvement at 1 year post procedure, 73% at 2 years and 70% at 3 years.
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